Uptown Girl is a woman in her early 20's living in Minneapolis, Minnesota. She is a reporter for a local newspaper "The Twin Cities Times", where she writes human interest stories and the occasional news piece. When not interviewing subjects for the paper, Uptown Girl hangs out with her friends, Ruby Tuesday and Rocketman, or at home with her cat Plinko, working on her novel.

Uptown Girl goes out of her way to help anyone at any time, often to the annoyance of her friends. While gathering information for a news story, she often ends up in dangerous situations due to her determination to find and report the truth. This dedication earns her the strong respect of her editor, Mean Mr. Mustard. She is also very supportive of her friends and their passions (be it video games or cartooning), even though they don't understand her zealous optimism for the world.